hyperglycemia treatments
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Hyperglycemia Treatments
Hyperglycemia definition
High blood sugar, or hyperglycemia, generally refers to blood glucose levels above normal values: fasting blood sugar over 6.1 mmol/L or post-meal blood sugar over 7.8 mmol/L. This common metabolic condition can lead to various complications, heightening the risk of cardiovascular diseases and significantly impacting health.
Hyperglycemia symptoms:
Frequent Hunger: Persistent hunger and a sudden increase in appetite, often with a craving for sweets, are common signs of hyperglycemia.
Excessive Thirst: Hyperglycemia can cause increased thirst and water intake.
Low Energy: Individuals may feel fatigued, complain of frequent tiredness, and experience persistent drowsiness.
Frequent Urination: Urination frequency may increase, sometimes exceeding 20 times a day, with larger volumes, foamy urine, and sticky or whitish urine residue.
Unexplained Weight Loss: Hyperglycemia can lead to sudden weight loss.
Eye Problems: Hyperglycemia can cause symptoms such as dry, gritty eyes, blurry or decreased vision, watery eyes in windy conditions, and unexpected retinal issues.
Skin Problems: The skin may become dry and itchy.
Slow-Healing Wounds: Hyperglycemia can impair wound healing, leading to a higher risk of infection.
Major Health Risks of hyperglycemia:
Vascular Damage: Hyperglycemia can harm endothelial cells within blood vessels, leading to abnormal vascular function and increased risk of cardiovascular events like heart attacks and strokes.
Nerve Damage: Prolonged hyperglycemia can damage the nervous system, causing peripheral neuropathy, including numbness and pain in the hands and feet. Severe cases may lead to leg ulcers and gangrene.
Kidney Damage: Hyperglycemia can harm the glomeruli, causing kidney dysfunction that can develop into diabetic nephropathy and, in severe cases, may require dialysis or a kidney transplant.
Eye Damage: Hyperglycemia can cause retinal damage, leading to vision loss or even blindness.
Traditional Chinese Medicine explanation of hyperglycemia
Blood sugar is a refined substance derived from the transformation of food. Its essence is glucose, primarily formed through the breakdown of starchy staple foods. Once glucose enters the bloodstream, it is referred to as blood sugar.
After food is digested and absorbed, the starchy components are converted into glucose, which then enters the bloodstream. As the blood circulates, it transports glucose throughout the body and into the cells, where it participates in metabolic processes and releases energy for the body's use. Any excess glucose that the body doesn't utilize is converted into glycogen under the regulation of insulin, which is stored in the liver, known as liver glycogen.
When the concentration of blood sugar in the bloodstream is insufficient, liver glycogen quickly breaks down into glucose, replenishing the blood and maintaining stable blood sugar levels.
If, for some reason, blood sugar levels remain elevated, this condition is referred to as hyperglycemia. In simpler terms, hyperglycemia means there is too much glucose in the blood.
It's important to correct a common misconception: many people believe high blood sugar is due to excess sugar in the body, but that's not the case! High blood sugar simply means there is too much glucose in the blood, while the cells throughout the body are in a state of severe glucose deficiency, effectively leaving the body with no usable sugar.
Root cause of hyperglycemia
So, what causes blood sugar levels to remain elevated? There are two main reasons:
Glucose cannot enter the cells to participate in various metabolic activities and remains in the bloodstream.
Excess glucose in the blood cannot enter the liver, preventing it from being synthesized into glycogen for storage.
What facilitates the transport of glucose into the cells for metabolism, and what allows glucose to enter the liver for glycogen synthesis? Western medicine attributes this to insulin! Whether it's allowing glucose to enter the cells for metabolism or entering the liver to synthesize glycogen, both processes require the regulation of insulin.
Hyperglycemia treatments by Western Medicine
As we know, diabetic patients often rely on insulin, and Western medicine frequently states that insulin is the only hormone in the body that can lower blood sugar. This is because the entire process of glucose metabolism—comprising the breakdown of glycogen into glucose, the synthesis of glycogen from glucose, and the entry of glucose into cells for metabolism—is all carried out under the regulation of insulin.
Based on this understanding, Western medicine views diabetes as an incurable condition that cannot be treated, only managed through continuous injections of synthetic insulin to control blood sugar levels. After diabetic patients receive insulin, their blood sugar quickly returns to normal levels.
So, can we understand it this way: as long as the concentration of insulin in the body is sufficient, blood sugar can remain stable! We could even say that the direct cause of high blood sugar is insufficient insulin levels in the body. The reasoning is straightforward: as soon as synthetic insulin is injected, blood sugar levels can rapidly decrease to normal.
Western medicine considers insulin to be the key to lowering blood sugar, and insulin is a hormone secreted by the pancreas. However, TCM does not have the concept of the pancreas as a separate entity; instead, it views the pancreas as an accessory organ of the spleen, referred to as "san gao."
As mentioned earlier, blood sugar is a refined substance derived from food, constituting part of the essence of that food. This essence is transformed by the spleen, which is why Traditional Chinese Medicine (TCM) believes that diabetes is closely related to the spleen's function.
Thus, if the spleen's function is weakened, glucose from the essence of food cannot enter the cells normally and instead remains in the bloodstream or is excreted through urine, resulting in high blood sugar. Conversely, if the spleen's function is normal, the essence of food can enter the cells properly, participate in various metabolic processes, and high blood sugar will no longer exist.
The underlying cause of high blood sugar also suggests its treatment method. Based on this understanding, TCM believes that the treatment for high blood sugar is to strengthen the spleen and enhance its ability to transform and transport nutrients.
Hyperglycemia treatments by Traditional Chinese Medicine
To summarize the treatment approach for high blood sugar: supplementing insulin can lower blood sugar, indicating that high blood sugar results from insufficient insulin levels. Since insulin is secreted by the pancreas, which is part of the spleen, enhancing spleen function can promote insulin secretion.
Therefore, by strengthening the spleen's transforming function, we can ensure that the pancreas secretes an adequate amount of insulin, effectively eliminating high blood sugar.
This is the fundamental approach of TCM for treating high blood sugar.
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Abstracts of professional journal articles
Metformin is the first choice and full course drug for Western medicine to treat type 2 diabetes, as well as the first choice drug for single drug treatment and combined treatment. It has a very wide audience, was once called "antidiabetic drug" by patients, and is currently one of the most widely used oral antidiabetic drugs in the world.
Recently, researchers from Fudan University and Guangxi Medical University published a research paper titled "A mechanical analysis of metformin's bipolar effects on life span and health span in C.elegans: Elixir in youth, poison in elder" in the journal "Mechanisms of Aging and Development". Research has shown that metformin has a biphasic effect on the lifespan of nematodes. Metformin can extend the lifespan of young nematodes by 11.1%, but shorten the lifespan of elderly nematodes by 22.2%.
Research has shown that metformin has a biphasic effect on regulating lifespan and healthy lifespan at different stages of life. It is beneficial for young nematodes but harmful for elderly nematodes, making it a "panacea for young people and a poison for the elderly". This research result highlights the complex interaction between the lifecycle and drug intervention.
It is worth mentioning that previously, Wang Fugui, Min Junxia and others from the School of Medicine at Zhejiang University published a research paper titled "Metformin potentials nephrotoxicity by promoting NETosis in response to renal ferroptosis" in the journal Cell Discovery under Nature. Research has shown that even low-dose metformin can induce acute kidney injury in mice, with nephrotoxicity and increased risk of death. The use of metformin after acute kidney injury can lead to the death of renal parenchymal cells and the expansion of neutrophils. Further investigation revealed that renal parenchymal cell death is a programmed cell death caused by ferroptosis, and blocking ferroptosis can prevent metformin induced nephrotoxicity.
The above references:
https://doi.org/10.1016/j.mad.2024.111963
https://doi.org/10.1038/s41421-023-00595-3